Sideroblastic Anemia in Multiple Myeloma: A Preleukemic Change
نویسندگان
چکیده
منابع مشابه
Sideroblastic anemia in multiple myeloma: a preleukemic change.
In a 10-yr observation period, 75 patients with multiple myeloma have been studied, and 55 of these were treated daily with low dose melphalan by mouth. Of these, four developed sideroblastic anemia, manifested by anemia, thrombocytopenia, aniso-poikilocytosis, and hypochromic stippled cells in the blood, and ringed sideroblasts in the bone marrow. In two patients, this complication occurred af...
متن کاملSideroblastic anemia.
When first defined 50 years ago, sideroblastic anemia (SA) was already recognized to occur in heterogeneous settings, including as familial or acquired disease. The spectrum of SA has since become considerably expanded with respect to distinct clinical phenotypes as well as discrete causes. The singular feature that typifies all forms of SA and is required for initial diagnosis is the presence ...
متن کاملAbnormal iron incorporatin, survival protoporphyrin content and fluorescence of one red cell population in preleukemic sideroblastic anemia.
The dimorphic blood picture in sideroblastic anemia suggests the coexistence of at least two types of erythrocyte, the populations with the smaller RBCs being responsible for the crucial abnormality, namely the impairment of iron incorporation into protoporphyrin. In a patient with sideroblastic anemia who subsequently developed acute myelocytic leukemia, we found a light and a heavy cell popul...
متن کاملAbnormal Iron Incorporation, Survival, Protoporphyrin Content and Fluorescence of One Red Cell Population in Preleukemic Sideroblastic Anemia
The dimorphic blood picture in sideroblastic anemia suggests the coexistence of at least two types of erythrocyte, the populations with the smaller RBCs being responsible for the crucial abnormality, namely the impairment of iron incorporation into protoporphyrin. In a patient with sideroblastic anemia who subsequently developed acute myelocytic leukemia, we found a light and a heavy cell popul...
متن کاملAnemia in Multiple Myeloma and Its Management.
Anemia is a frequent finding in patients with myeloma, second only to skeletal lytic lesions. Approximately 70% of patients have anemia at diagnosis a median hemoglobin of approximately 10.5 g/dL. The severity of anemia is important in determining the stage and prognosis of disease as determined by the Durie and Salmon staging criteria. Like anemia of chronic disease, the anemia of myeloma is g...
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ژورنال
عنوان ژورنال: Blood
سال: 1973
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v41.1.17.17